منابع مشابه
Familial apolipoprotein A-I and C-III deficiency, variant II.
The biochemical, clinical, and genetic features were examined in the proband (homozygote) and heterozygotes (n = 17) affected with familial apolipoprotein A-I and C-III deficiency, variant II (previously described as apolipoprotein A-I absence). The proband was a 45-year-old white female with mild corneal opacification and significant three-vessel coronary artery disease (CAD), who died shortly...
متن کاملApolipoprotein A-I Q[-2]X causing isolated apolipoprotein A-I deficiency in a family with analphalipoproteinemia.
We report a Canadian kindred with a novel mutation in the apolipoprotein (apo) A-I gene causing analphalipoproteinemia. The 34-yr-old proband, product of a consanguineous marriage, had bilateral retinopathy, bilateral cataracts, spinocerebellar ataxia, and tendon xanthomata. High density lipoprotein cholesterol (HDL-C) was < 0.1 mM and apoA-I was undetectable. Genomic DNA sequencing of the prob...
متن کاملApolipoprotein A-I Therapy
Since 1988, with the release of the National Cholesterol Education Panel (NCEP) Adult Treatment Panel I, lowdensity lipoprotein cholesterol (LDL-C) has been the primary focus of therapy (1). Although the total cholesterol to high-density lipoprotein cholesterol (HDL-C) ratio is a better cardiovascular risk predictor (2), the consensus at the time was that the clinical evidence only supported LD...
متن کاملApolipoprotein A-V Deficiency Enhances Chylomicron
9 10 11 12 13 14 15 Linda S. Zhang 1 , Min Xu 1 , Qing Yang 1 , Robert O. Ryan 2 , Philip Howles 1 , Patrick Tso 1 16 17 18 19 20 21 22 23 1. Department of Pathology and Laboratory Medicine, University of Cincinnati College of 24 Medicine, Cincinnati, OH 45215 25 2. Children's Hospital Oakland Research Institute, Oakland, CA 94609 26 27 28 29 Running Head: ApoA-V Deficiency Enhances Chylomicron...
متن کاملApolipoprotein A-I mimetic peptides.
Despite identical amino acid composition, differences in class A amphipathic helical peptides caused by differences in the order of amino acids on the hydrophobic face results in substantial differences in antiinflammatory properties. One of these peptides is an apolipoprotein A-I (apoA-I) mimetic, D-4F. When given orally to mice and monkeys, D-4F caused the formation of pre-beta high-density l...
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ژورنال
عنوان ژورنال: Arteriosclerosis, Thrombosis, and Vascular Biology
سال: 1995
ISSN: 1079-5642,1524-4636
DOI: 10.1161/01.atv.15.12.2157